Gery Atanasova Gery Atanasova

The Role of Vitamin D in Juvenile Arthritis Management

.Most children who have JIA are deficient in Vitamin D. This deficiency is not significantly influenced by disease management therapies or genetic variants of the vitamin D receptor.

Key findings include:

• Dietary Intake and Supplementation: Children with JIA often have lower dietary vitamin D intake than recommended. Standard supplementation doses (500–2,000 IU/day) are frequently insufficient to meet their needs.

• Immune Modulation: Vitamin D plays a role in immune regulation, and its deficiency may exacerbate autoimmune processes in JIA.

• Impact of Therapies: Methotrexate (MTX) therapy has been associated with lower vitamin D levels, suggesting a potential iatrogenic effect.

Vitamin D supplementation should be considered for all children with JIA, especially those on long-term MTX therapy, to address both deficiency and potential immune benefits.

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